Levofloxacin and Amikacin Adsorption on Nanodiamonds: Mechanism and Application Prospects

This research is focused on the adsorption modification of detonation nanodiamond surfaces with antibiotics for their further use as smart materials cardiovascular surgery purposes, namely bioprostheses modifiers. Tritium-labeled amikacin and levofloxacin were used tracers process control. We found that nanodiamonds form complexes via physical adsorption, while in case amikacin, electrostatic attraction contributes to formation more stable complexes, even presence electrolytes desorbing agents (models biological fluids). Antimicrobial characterization nanodiamond–levofloxacin nanodiamond–amikacin indicates a reduction dose an antimicrobial agent. Therefore, biomaterial based DND basis will allow one either avoid or significantly reduce duration intensity postoperative period, which critically important from viewpoint development antibiotic resistance pathogens.